Impact of Mucin Cellularity and Distribution on Survival in Newly Diagnosed Patients with Low-Grade Appendiceal Mucinous Neoplasm Treated with Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy.
Andrei NikiforchinMary Caitlin KingEkaterina BaronRyan MacDonaldMichelle SittigCarol NierodaVadim GushchinArmando SardiPublished in: Annals of surgical oncology (2020)
Despite comparable CC rates after CRS/HIPEC, CM patients have shorter PFS than AM patients. In CM patients, more zones with cells, but not the total number of involved zones, negatively impact PFS. Mucin type does not impact OS. It is important to assess and report mucin cellularity in LAMN specimens.
Keyphrases
- newly diagnosed
- low grade
- end stage renal disease
- chronic kidney disease
- ejection fraction
- prognostic factors
- high grade
- squamous cell carcinoma
- coronary artery disease
- minimally invasive
- cell proliferation
- cell death
- oxidative stress
- patient reported outcomes
- free survival
- endoplasmic reticulum stress
- ultrasound guided
- rectal cancer