NLRP3 inflammasome activation and altered mitophagy are key pathways in inclusion body myositis.

Elie NaddafThi Kim Oanh NguyenJens O WatzlawikHuanyao GaoXu HouFabienne C FieselJay MandrekarEileen KokeshWilliam S HarmsenIan R LanzaWolfdieter SpringerEugenia Trushina

Published in: medRxiv : the preprint server for health sciences (2024)

NLRP3 inflammasome is activated in IBM, along with altered mitophagy particularly in males, which is of potential therapeutic significance. These findings suggest sex-specific mechanisms in IBM that warrant further investigation.

Keyphrases

nlrp inflammasome
interstitial lung disease
systemic sclerosis
myasthenia gravis