Coxsackievirus Adenovirus Receptor Loss Impairs Adult Neurogenesis, Synapse Content, and Hippocampus Plasticity.
Charleine ZussyFabien LoustalotFelix JunyentFabrizio GardoniCyril BoriesJorge ValeroMichel G DesarménienFlorence BernexDaniel HenaffNeus Bayó-PuxanJin-Wen ChenNicolas LonjonYves de KoninckJoão O MalvaJeffrey M BergelsonMonica Di LucaGiampietro SchiavoSara SalinasEric J KremerPublished in: The Journal of neuroscience : the official journal of the Society for Neuroscience (2017)
This study addressed the role of the coxsackievirus and adenovirus receptor (CAR), a single-pass cell adhesion molecule, in the adult brain. Our results demonstrate that CAR is expressed by mature neurons throughout the brain. In addition, we propose divergent roles for CAR in immature neurons, during neurogenesis, and at the mature synapse. Notably, CAR loss of function also affects hippocampal plasticity.