Hydrocortisone metabolism by Staphylococcus: effects on anti-inflammatory and antimicrobial action.

Lisa Mary CherianSha LiuKaren HonMahnaz RamezanpourHua HuShari JavadiyanIrene StaffordPeter-John WormaldAlkis James Psaltis FracsSarah Vreugde

Published in: International forum of allergy & rhinology (2023)

Hydrocortisone 21-hemisuccinate (HCHS), influenced the growth and metabolism of S. aureus S. aureus metabolic activity was high and antibiotic susceptibility low at 1.4mg/ml HCHC. S. aureus metabolised HCHS to cortisol and reduced poly (I:C) induced IL-6 secretion. This article is protected by copyright. All rights reserved.

Keyphrases

staphylococcus aureus
anti inflammatory
septic shock
high glucose
diabetic rats
biofilm formation
drug induced
oxidative stress
cystic fibrosis