Sodium Tanshinone IIA Sulfonate Ameliorates Injury-Induced Oxidative Stress and Intervertebral Disc Degeneration in Rats by Inhibiting p38 MAPK Signaling Pathway.

Shou-Qian Dai Xiu ShiRongqing QinXing Zhang Feng Xu Zong-Ping Luo

Published in: Oxidative medicine and cellular longevity (2021)

STS ameliorated injury-induced intervertebral disc degeneration and displayed anti-inflammatory and antioxidative properties in a rat model of IDD, possibly via inhibition of the p38 MAPK signaling pathway.

Keyphrases

signaling pathway
anti inflammatory
pi k akt
epithelial mesenchymal transition
induced apoptosis
high glucose
diabetic rats
hydrogen peroxide
drug induced
oxidative stress
cell proliferation