Increased frequency of proinflammatory CD4 T cells and pathological levels of serum neurofilament light chain in adult drug-resistant epilepsy.
Oumarou OuédraogoRose-Marie RébillardHélène JamannVictoria Hannah MamaneMarie-Laure ClénetAudrey DaigneaultBoaz LahavTimo UphausFalk SteffenStefan BittnerFrauke ZippArline BérubéSamuel Lapalme-RemisPatrick CossetteDang Khoa NguyenNathalie ArbourMark R KeezerCatherine LarochellePublished in: Epilepsia (2020)
Our data support that DRE is associated with an expansion of the CD4 Tcell subset in the peripheral blood and with a shift toward a proinflammatory Th17/Th1 CD4 Tcell immune profile. Our results further show that pathological levels of sNfL are more frequent in DRE, supporting a potential neurodegenerative component in adult DRE. With this work, we provide evidence for novel potential inflammatory and degenerative biomarkers in DRE.