Overexpression of TK1 and CDK9 in plasma-derived exosomes is associated with clinical resistance to CDK4/6 inhibitors in metastatic breast cancer patients.

Marzia Del ReIlaria BertoliniStefania CrucittaLorenzo FontanelliEleonora RofiClaudia De AngelisLucrezia DiodatiDiletta CavalleroGiulia GianfilippoBarbara SalvadoriStefano FogliAlfredo FalconeCristian ScatenaAntonio Giuseppe NaccaratoManuela RoncellaMatteo GhilliRiccardo MorgantiAndrea FontanaRomano Danesi

Published in: Breast cancer research and treatment (2019)

The present study demonstrates that, in plasma-derived exosomes, high baseline CDK4 mRNA levels are associated with response to palbociclib plus hormonal therapy, while the increase in TK1 and CDK9 mRNA copies/ml is associated with clinical resistance.

Keyphrases

cell cycle
mesenchymal stem cells
cell proliferation
stem cells
squamous cell carcinoma
binding protein
type diabetes
adipose tissue
metastatic breast cancer
replacement therapy