Integrative Cistromic and Transcriptomic Analyses Identify CREB Target Genes in Cystic Renal Epithelial Cells.

Zhiheng LiuYunjing LiuLin DangMeijuan GengYongzhan SunYi LuZhongze FangHui XiongYupeng Chen

Published in: Journal of the American Society of Nephrology : JASN (2021)

CREB promotes cystogenesis by activating ribosome biogenesis genes. CUT&RUN, coupled with transcriptomic analysis, enables interrogation of TF binding and identification of direct TF targets from a low number of specific kidney cells.

Keyphrases

bioinformatics analysis
induced apoptosis
genome wide
signaling pathway
genome wide identification
cell cycle arrest
dna methylation
endoplasmic reticulum stress
genome wide analysis
gene expression
cell death
cell proliferation
dna binding
transcription factor
network analysis