Integrative Cistromic and Transcriptomic Analyses Identify CREB Target Genes in Cystic Renal Epithelial Cells.
Zhiheng LiuYunjing LiuLin DangMeijuan GengYongzhan SunYi LuZhongze FangHui XiongYupeng ChenPublished in: Journal of the American Society of Nephrology : JASN (2021)
CREB promotes cystogenesis by activating ribosome biogenesis genes. CUT&RUN, coupled with transcriptomic analysis, enables interrogation of TF binding and identification of direct TF targets from a low number of specific kidney cells.