A novel trypsin of Trichinella spiralis mediates larval invasion of gut epithelium via binding to PAR2 and activating ERK1/2 pathway.

Lu Lu HanQi Qi LuWen Wen ZhengYang Li LiYan Yan SongXin Zhuo ZhangShao Rong LongRuo Dan LiuZhong Quan WangJing Cui

Published in: PLoS neglected tropical diseases (2024)

TsTryp binding to PAR2 activated the ERK1/2 pathway, decreased the expression of gut TJs proteins, disrupted epithelial integrity and barrier function, and consequently mediated larval invasion of the gut mucosa. Therefore, rTsTryp could be regarded as a potential vaccine target for blocking T. spiralis invasion and infection.

Keyphrases

signaling pathway
cell migration
cell proliferation
pi k akt
aedes aegypti
drosophila melanogaster
binding protein
risk assessment
human health