Polygenic risk scores predict diabetes complications and their response to intensive blood pressure and glucose control.
Johanne TremblayMounsif HalouiRedha AttaouaMuhammad Ramzan TahirCamil HishmihFrançois HarveyFrançois-Christophe Marois-BlanchetCarole LongPaul SimonLara SantucciCandan HizelJohn ChalmersMichel MarreStephen B HarrapRenata CífkováAlena KrajčoviechováDavid R MatthewsBryan WilliamsNeil R PoulterSophia ZoungasStephen ColagiuriGiuseppe ManciaDiederick E GrobbeeAnthony RodgersLiusheng LiuMawussé AgbessiVanessa BruatMarie-Julie FavéMichelle P HarwoodPhillip AwadallaMark WoodwardJulie G HussinPavel HametPublished in: Diabetologia (2021)
This novel multiPRS model stratified individuals with type 2 diabetes according to risk of complications and helped to target earlier those who would receive greater benefit from intensive therapy.