Continuous evaluation of single-dose moxifloxacin concentrations in brain extracellular fluid, cerebrospinal fluid, and plasma: a novel porcine model.

Theis MariagerJ H TerkelsenM BueK Öbrink-HansenR NauC R BjarkamHenrik Nielsen Jacob Bodilsen

Published in: The Journal of antimicrobial chemotherapy (2024)

A single dose of weight-adjusted moxifloxacin administered intravenously did not achieve adequate target site concentrations within the uninflamed porcine brain ECF and CSF to reach the applied TB CNS target.

Keyphrases

cerebrospinal fluid
resting state
white matter
functional connectivity
mycobacterium tuberculosis
cerebral ischemia
body mass index
blood brain barrier
physical activity
weight gain
multiple sclerosis
brain injury
body weight
subarachnoid hemorrhage