A calcium channel blocker, manoalide exerts an anti-allergic inflammatory effect through attenuating NF-κB activity.

Jun-Ho YeomHee-Yun KimJin-Ho LimKyoung Wan YoonHyung-Min KimHyun-Ja Jeong

Published in: Immunopharmacology and immunotoxicology (2021)

Taken together, our findings indicate manoalide has an anti-allergic inflammatory role, and we propose that manoalide might have potential as a novel anti-allergic inflammatory agent.

Keyphrases

oxidative stress
allergic rhinitis
signaling pathway
atopic dermatitis
lps induced
immune response
cell proliferation
nuclear factor
pi k akt
climate change
inflammatory response
toll like receptor