Monitoring Methylmalonic Aciduria by NMR Urinomics.

Alina NicolescuDaniela BlanitaChiril BoiciucVictoria HlistunMihaela CristeaDorina RotaruLudmila PinzariAna OglindaAdela StamatiIsabela Tarcomnicu Andreea Tutulan-CunitaDanae StambouliSergiu GladunNinel RevencoNatalia UşureluCalin Deleanu

Published in: Molecules (Basel, Switzerland) (2020)

The paper reports on monitoring methylmalonic aciduria (MMA)-specific and non-specific metabolites via NMR urinomics. Five patients have been monitored over periods of time; things involved were diet, medication and occasional episodes of failing to comply with prescribed diets. An extended dataset of targeted metabolites is presented, and correlations with the type of MMA are underlined. A survey of previous NMR studies on MMA is also presented.

Keyphrases

magnetic resonance
high resolution
end stage renal disease
solid state
ms ms
weight loss
newly diagnosed
chronic kidney disease
peritoneal dialysis
physical activity
adverse drug
patient reported outcomes