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The DNA Damage Response and Inflammation in Cancer.

Vanessa KlappBeatriz Álvarez-AbrilGiuseppe LeuzziGuido KroemerAlberto CicciaLorenzo Galluzzi
Published in: Cancer discovery (2023)
Accumulating preclinical and clinical evidence indicates that DDR is intimately connected to the emission of immunomodulatory signals by normal and malignant cells, as part of a cell-extrinsic program to preserve organismal homeostasis. DDR-driven inflammation, however, can have diametrically opposed effects on tumor-targeting immunity. Understanding the links between the DDR and inflammation in normal and malignant cells may unlock novel immunotherapeutic paradigms to treat cancer.
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