Nucleotide Pool Imbalance and Antibody Gene Diversification.
Asim AzharNasim A BegumAfzal HusainPublished in: Vaccines (2021)
The availability and adequate balance of deoxyribonucleoside triphosphate (dNTP) is an important determinant of both the fidelity and the processivity of DNA polymerases. Therefore, maintaining an optimal balance of the dNTP pool is critical for genomic stability in replicating and quiescent cells. Since DNA synthesis is required not only in genomic replication but also in DNA damage repair and recombination, the abnormalities in the dNTP pool affect a wide range of chromosomal activities. The generation of antibody diversity relies on antigen-independent V(D)J recombination, as well as antigen-dependent somatic hypermutation and class switch recombination. These processes involve diverse sets of DNA polymerases, which are affected by the dNTP pool imbalances. This review discusses the role of the optimal dNTP pool balance in the diversification of antibody encoding genes.
Keyphrases
- dna damage
- copy number
- circulating tumor
- dna repair
- cell free
- single molecule
- genome wide
- induced apoptosis
- oxidative stress
- nucleic acid
- dna methylation
- cell cycle arrest
- genome wide identification
- cell death
- circulating tumor cells
- cell proliferation
- signaling pathway
- bioinformatics analysis
- genome wide analysis
- pi k akt