Dynamic alteration and prognostic significance of tumor-associated CD68 + and CD68 + PD-L1 - macrophages in muscle-invasive bladder cancer treated with neoadjuvant chemotherapy.

TAMs infiltration levels decreased significantly after NAC and pre-treatment TAM infiltration levels were independent prognostic factors for MIBC patients. While there was no sufficient evidence demonstrating that pre-treatment TILs or TAMs could predict response to NAC in MIBC patients.