Detection and Genotyping of High-Risk Human Papillomavirus among Male Patients during 2015-2023 in Beijing, China.

Few researches focused on human papillomavirus (HPV) in male patients. This study aimed to explore the detection rate and genotyping of HPV among male patients in Beijing to provide a reference for formulating prevention strategies for HPV infection. The cross-sectional study was conducted in Beijing Chaoyang Hospital from November 2015 to March 2023. It covered male patients from urology and dermatology departments. Fifteen high-risk HPV genotypes were detected by the multiplex real-time polymerase chain reaction method. The detection rate of HPV and 95% confidence interval (CI) were calculated. The overall detection rate of HPV was 25.19% (1288/5114, 95% CI 24.00%-26.38%), of which the single infection rate was 16.99% (869/5114, 95% CI 15.97%-18.05%) and the co-infection rate was 8.19% (419/5114, 95% CI 7.46%-8.98%). The detection rate of HPV was 40.77% (521/1278), 35.58% (58/163), 32.69% (101/309), 31.91% (60/188), 12.63% (299/2367) and 32.35% (131/405) among male patients with balanitis, warts, rash, urethritis, prostatitis and other urinary inflammation, respectively ( P  < 0.001). The top five HPV genotypes were HPV-52, HPV-58, HPV-16, HPV-51, and HPV-66. After the first positive HPV test, the proportion of male patient who turned negative was 22.47% within 3 months, 26.40% within 3-6 months, 24.72% within 6-12 months, 17.98% within 12-24 months and 8.43% more than 24 months. The detection rate of HPV was high among male patients from urology and dermatology departments in Beijing. HPV-52 and HPV-58 were the predominant genotypes, which should be considered to develop HPV vaccines with better prevention effect.