Alpha-Synuclein Oligomers and Neurofilament Light Chain in Spinal Fluid Differentiate Multiple System Atrophy from Lewy Body Synucleinopathies.
Wolfgang SingerAnn M SchmeichelMohammad ShahnawazJames D SchmelzerBradley F BoeveDavid M SlettenTonette L GehrkingJade A GehrkingAnita D OlsonRodolfo SavicaMariana D SuarezClaudio SotoPhillip A LowPublished in: Annals of neurology (2020)
NFL and αSyn oligomers in CSF faithfully differentiate early MSA not only from CON but also from Lewy body synucleinopathies. The findings support the role of these markers as diagnostic biomarkers, and have important implications for understanding pathophysiologic mechanisms underlying the synucleinopathies. ANN NEUROL 2020;88:503-512.