A supramolecular nanoprodrug based on a boronate ester linked curcumin complexing with water-soluble pillar[5]arene for synergistic chemotherapies.

Shuang ChaoXiukai LvNing MaZiyan ShenFeiyu ZhangYuxin Pei Zhichao Pei

Published in: Chemical communications (Cambridge, England) (2021)

A supramolecular nanoprodrug based on the host-guest complexation of water-soluble pillar[5]arene (WP5) and a boronate ester linked curcumin (Cur) was constructed, which had dual-responsiveness towards pH and GSH, allowing the drug to be selectively released in hepatoma cells. In vitro studies revealed that the Dox-loaded WP5G-Cur nanoprodrug achieved co-delivery of Dox/Cur. The anti-cancer efficiency could be enhanced through synergistic chemotherapies of Dox/Cur.

Keyphrases

water soluble
cancer therapy
induced apoptosis
drug delivery
cell cycle arrest
wastewater treatment
single cell
emergency department
oxidative stress
endoplasmic reticulum stress
cell proliferation
fluorescent probe
drug induced