Adaptive study design to assess effect of TRPV4 inhibition in patients with chronic cough.

Valerie J LudbrookKate E HanrottJames L KreindlerJoanna E Marks-KonczalikNick P BirdDebbie A HewensMisba BeeraheeDavid J BehmAlyn Hugh MoriceLorcan McGarveySean M ParkerSurinder S BirringJaclyn Ann Smith

Published in: ERJ open research (2021)

There was no evidence of an anti-tussive effect of GSK2798745. The study design allowed the decision on lack of efficacy to be made with minimal participant exposure to the investigational drug.

Keyphrases

signaling pathway
pi k akt
neuropathic pain
decision making
phase ii
adverse drug
clinical trial
drug induced
emergency department
spinal cord
cell proliferation