Syk Activation in Circulating and Tissue Innate Immune Cells in Antineutrophil Cytoplasmic Antibody-Associated Vasculitis.
Maria F PrendeckiKavita GulatiNoelle PisacanoDamilola PinheiroTejal BhattMarie-Anne MawhinFrederic ToulzaEsteban S MasudaAndrew CowburnKatharine M LodgeFrederick W K TamCandice RoufosseCharles D PuseyStephen P McAdooPublished in: Arthritis & rheumatology (Hoboken, N.J.) (2022)
These findings indicate that Syk plays a critical role in MPO-ANCA IgG-induced myeloid cell responses and that Syk is activated in circulating immune cells and tissue immune cells in AAV; therefore, Syk inhibition may be a potential therapeutic option.