Novel magnetic resonance KTRANS measurement of blood-brain barrier permeability correlated with covert HE.
Joga ChagantiGeorgia ZengNway TunIan LockartChristina Abdel ShaheedLucette CysiqueSara MontagneseBruce J BrewThomas BergPublished in: Hepatology communications (2023)
The dynamic contrast-enhanced MRI KTRANS measurement revealed increased blood-brain barrier permeability in the frontoparietal cortex. The MRS identified a specific metabolite signature with increased glutamine, reduced myo-inositol, and choline, which correlated with CHE in this region. The MRS changes were identifiable in the NHE cohort.