Carrier-Free Self-Assembled Nanomedicines for Promoting Apoptosis and Inhibiting Proliferation in Hepatocellular Carcinoma.
WeiLu JiaMeng YangWenNing ZhangWenJing XuYewei ZhangPublished in: ACS biomaterials science & engineering (2024)
In order to improve the effectiveness of tumor treatment and reduce the toxic side effects of drugs, we formed carrier-free multifunctional nanoparticles (BI NPs) by noncovalent interaction of berberine hydrochloride and IR780. BI NPs possessed the synergistic effects of promoting apoptosis, inhibiting proliferation and metastasis of tumors, and phototherapeutic treatment. Dispersive and passive targeting ability retention (EPR) effects of BI NPs on tumor sites in vivo could be monitored by fluorescence imaging. In addition, BI NPs exhibited effective reactive oxygen species (ROS) generation and photothermal conversion capabilities, photodynamic therapy (PDT), and photothermal therapy (PTT). Importantly, BI NPs inhibit tumor suppression through the AMPK/PI3K/AKT signaling pathway to inhibit tumor proliferation and metastasis. BI NPs not only have efficient in vivo multimodal therapeutic effects but also have good biosafety and potential clinical applications.
Keyphrases
- signaling pathway
- pi k akt
- photodynamic therapy
- cell cycle arrest
- fluorescence imaging
- reactive oxygen species
- induced apoptosis
- cancer therapy
- epithelial mesenchymal transition
- cell death
- oxide nanoparticles
- endoplasmic reticulum stress
- drug delivery
- systematic review
- cell proliferation
- mass spectrometry
- pain management
- ionic liquid
- gas chromatography mass spectrometry
- tandem mass spectrometry
- solid phase extraction