Accelerated brain aging as a biomarker for staging in bipolar disorder: an exploratory study.
Afra van der MarktUrsula M H KlumpersAnnemieke DolsNicole KortenMarco P M BoksRoel A OphoffAartjan T F BeekmanRalph W KupkaNeeltje E M van HarenHugo G SchnackPublished in: Psychological medicine (2023)
These results suggest that brain-PAD may be associated with illness progression as defined by impaired inter-episodic functioning. Nevertheless, the significance of this association changed after considering lithium-use and comorbid anxiety disorders. Further research is required to disentangle the intricate relationship between brain-PAD, illness stages, and lithium intake or anxiety disorders. This study provides a foundation for potentially using brain-PAD as a biomarker for illness progression.