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Accelerated brain aging as a biomarker for staging in bipolar disorder: an exploratory study.

Afra van der MarktUrsula M H KlumpersAnnemieke DolsNicole KortenMarco P M BoksRoel A OphoffAartjan T F BeekmanRalph W KupkaNeeltje E M van HarenHugo G Schnack
Published in: Psychological medicine (2023)
These results suggest that brain-PAD may be associated with illness progression as defined by impaired inter-episodic functioning. Nevertheless, the significance of this association changed after considering lithium-use and comorbid anxiety disorders. Further research is required to disentangle the intricate relationship between brain-PAD, illness stages, and lithium intake or anxiety disorders. This study provides a foundation for potentially using brain-PAD as a biomarker for illness progression.
Keyphrases
  • resting state
  • bipolar disorder
  • white matter
  • functional connectivity
  • cerebral ischemia
  • lymph node
  • major depressive disorder
  • pet ct
  • weight loss
  • brain injury
  • subarachnoid hemorrhage
  • weight gain