DNA methylation of Th2 lineage determination genes at birth is associated with allergic outcomes in childhood.
Sheila J BartonS NgoP CostelloE GarrattSarah El-HeisE AntounR Clarke-HarrisR MurrayT BhattG BurdgeC CooperH InskipE M van der BeekA SheppardK M GodfreyK A Lillycropnull nullPublished in: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology (2017)
Our findings provide further evidence of a developmental contribution to the risk of later allergic disorders and suggest that involvement of epigenetic mechanisms in childhood asthma is already demonstrable at birth.
Keyphrases
- dna methylation
- allergic rhinitis
- genome wide
- gestational age
- gene expression
- early life
- chronic obstructive pulmonary disease
- lung function
- solid phase extraction
- molecularly imprinted
- single cell
- type diabetes
- pregnancy outcomes
- preterm birth
- genome wide identification
- skeletal muscle
- high resolution
- cell fate
- liquid chromatography
- genome wide analysis