Near-Infrared-to-Near-Infrared Optical Thermometer BaY 2 O 4 : Yb 3+ /Nd 3+ Assembled with Photothermal Conversion Performance.

Nowadays, the construction of photothermal therapy (PTT) agents integrated with real-time thermometry for cancer treatment in deep tissues has become a research hotspot. Herein, an excellent photothermal conversion material, BaY 2 O 4 : Yb 3+ /Nd 3+ , assembled with real-time optical thermometry is developed successfully. Ultrasensitive temperature sensing is implemented through the fluorescence intensity ratio of thermally coupled Nd 3+ : 4 F j ( j = 7/2, 5/2, and 3/2) with a maximal absolute and relative sensitivity of 68.88 and 3.29% K -1 , respectively, which surpass the overwhelming majority of the same type of thermometers. Especially, a thermally enhanced Nd 3+ luminescence with a factor of 180 is detected with irradiation at 980 nm, resulting from the improvement in phonon-assisted energy transfer efficiency. Meanwhile, the photothermal conversion performance of the sample is excellent enough to destroy the pathological tissues, of which the temperature can be raised to 319.3 K after 180 s of near-infrared (NIR) irradiation with an invariable power density of 13.74 mW/mm 2 . Besides, the NIR emission of Nd 3+ can reach a depth of 7 mm in the biological tissues, as determined by an ex vivo experiment. All the results show the potential application of BaY 2 O 4 : Yb 3+ /Nd 3+ as a deep-tissue PTT agent simultaneously equipped with photothermal conversion and temperature sensing function.