SOX9 is colocalized with paraspeckle protein NONO in cultured murine sertoli cells and features structural characteristics of intrinsically disordered proteins.

Kazuhisa AkibaSatoshi NarumiRiko NishimuraYuko Kato-FukuiShuji TakadaYukihiro HasegawaMaki Fukami

Published in: Molecular reproduction and development (2020)

This study provides supporting evidence for the association between SOX9 and liquid-liquid phase separation. We show that SOX9 colocalized with a paraspeckle protein NONO in many, but not all, of the immortalized and primary murine Sertoli cells examined. In addition, we confirmed that SOX9 has structural characteristics of intrinsically disordered proteins.

Keyphrases

induced apoptosis
transcription factor
stem cells
cell cycle arrest
endoplasmic reticulum stress
endothelial cells
oxidative stress
signaling pathway
cell death
binding protein