Presynaptic Dopaminergic Imaging Characterizes Patients with REM Sleep Behavior Disorder Due to Synucleinopathy.
Dario ArnaldiPietro MattioliStefano RaffaMatteo PardiniFederico MassaAlejandro IranzoAndres PerissinottiAida Niñerola-BaizánCarles GaigMonica SerradellAmaia Muñoz-LopetegiGerard MayàClaudio LiguoriMariana FernandesFabio PlacidiAgostino ChiaravallotiKarel ŠonkaPetr DušekDavid ZogalaJiri TrnkaBradley F BoeveToji MiyagawaVal J LoweTomoyuki MiyamotoMasayuki MiyamotoMonica PulighedduMichela FigorilliAlessandra SerraMichele T HuJohannes C KleinFrederik BesDieter KunzValérie Cochen De CockDelphine de VerbizierGiuseppe PlazziElena AntelmiMichele TerzaghiIrene BossertKristína KulcsárováAlessio MartinoAlessandro GiulianiMarco PaganiFlavio NobiliSilvia Morbellinull nullPublished in: Annals of neurology (2024)
Clinical data alone poorly predicted phenoconversion in RBD due to synucleinopathy patients. Conversely, presynaptic dopaminergic imaging allows a good prediction of forthcoming phenoconversion diagnosis. This finding may be used in designing future disease-modifying trials. ANN NEUROL 2024;95:1178-1192.