Three-Dimensional Hepatocyte Spheroids: Model for Assessing Chemotherapy in Hepatocellular Carcinoma.

Felix RoyoClara Garcia-VallicrosaMaria Azparren-AnguloGuillermo Bordanaba-Florit Silvia Lopez-Sarrio Juan Manuel Falcon-Perez

Published in: Biomedicines (2024)

Treatment of mixed spheroids with different cytotoxic drugs enables the characterization of drug effects on both hepatocytes and tumoral cells, determining drug specificity effects on these cell types.

Keyphrases

liver injury
drug induced
induced apoptosis
single cell
cell cycle arrest
cell therapy
adverse drug
locally advanced
squamous cell carcinoma
oxidative stress
signaling pathway
endoplasmic reticulum stress
cell proliferation
mesenchymal stem cells
rectal cancer