AMPK/SIRT1 Deficiency Drives Adjuvant-Induced Arthritis in Rats by Promoting Glycolysis-Mediated Monocytes Inflammatory Polarization.
Dan-Dan WangChi-Yi HeYi-Jin WuLiang XuChao ShiOpeyemi Joshua OlatunjiJian ZuoCong-Lan JiPublished in: Journal of inflammation research (2022)
SIRT1 deficiency is implicated in AIA-related immune abnormality and metabolism alteration. Activating this signaling with resveratrol would impair the inflammatory polarization of monocytes, and consequently ease the severity of RA.
Keyphrases
- oxidative stress
- diabetic rats
- rheumatoid arthritis
- dendritic cells
- ischemia reperfusion injury
- peripheral blood
- early stage
- high glucose
- replacement therapy
- signaling pathway
- drug induced
- skeletal muscle
- disease activity
- protein kinase
- immune response
- systemic lupus erythematosus
- interstitial lung disease
- systemic sclerosis
- stress induced