Nasal administration of recombinant Neospora caninum secreting IL-15/IL-15Rα inhibits metastatic melanoma development in lung.

Arthur BattistoniLouis LantierAnne di TommasoCéline DucournauLaurie LajoieMahtab SamimiLoïs CoënonClément RivièreMathieu EpardaudLeslie HertereauAgathe Poupée-BeaugéJuliette RieuMarie-Noëlle MévélecGordon Scott LeeNathalie MoiréStephanie GermonIsabelle Dimier-Poisson

Published in: Journal for immunotherapy of cancer (2023)

-demonstrated clear potential as an effective and safe immunotherapeutic approach for the treatment of metastatic solid cancers, whose existing therapeutic options are scarce. Combination of this armed protozoa with an intranasal route could reinforce the existing therapeutic arsenal against cancer and narrow the spectrum of incurable cancers.

Keyphrases

toxoplasma gondii
papillary thyroid
squamous cell carcinoma
small cell lung cancer
childhood cancer
smoking cessation
combination therapy
replacement therapy