Amyloid pathology and vascular risk are associated with distinct patterns of cerebral white matter hyperintensities: A multicenter study in 3132 memory clinic patients.
Johannes Matthijs BiesbroekMirthe CoenenCharles DeCarliEvan M FletcherPauline M Maillardnull nullFrederik BarkhofJosephine BarnesThomas BenkeChristopher P L H ChenPeter Dal-BiancoAnna DewenterMarco DueringChristian EnzingerMichael EwersLieza G ExaltoNicolai FranzmeierSaima HilalEdith HoferHuiberdina L KoekAndrea B MaierCheryl R McCrearyJanne M PapmaRoss W PatersonYolande A L PijnenburgAnna RubinskiReinhold SchmidtJonathan M SchottCatherine F SlatteryEric E SmithCarole H SudreRebecca M E SteketeeCharlotte E TeunissenEsther van den BergWiesje M van der FlierNarayanaswamy VenketasubramanianVikram VenkatraghavanMeike W VernooijFrank J WoltersXu XinHugo J KuijfGeert Jan BiesselsPublished in: Alzheimer's & dementia : the journal of the Alzheimer's Association (2024)
Key dementia etiologies may be associated with specific patterns of white matter hyperintensities (WMH). We related WMH locations to vascular risk and cerebral Aβ42 status in 11 memory clinic cohorts. Aβ42 positive status was associated with posterior WMH in splenium and posterior thalamic radiation. Vascular risk was associated with anterior and infratentorial WMH. Amyloid pathology and vascular risk have distinct signature WMH patterns.