Both acute and chronic inflammation are associated with less perineural invasion in men with prostate cancer on repeat biopsy.
Andrew G KuangJ Curtis NickelGerald L AndrioleRamiro Castro-SantamariaStephen J FreedlandDaniel M MoreiraPublished in: BJU international (2018)
Acute and chronic prostate inflammation were both associated with a lower prevalence of PNI in prostate biopsies positive for PCa. If confirmed, this suggests that inflammation and immunomodulation can serve as areas of potential therapeutic design to mitigate PNI in patients with PCa.