Characterizing the Clinical Features and Atrophy Patterns of MAPT-Related Frontotemporal Dementia With Disease Progression Modeling.
Alexandra L YoungMartina BocchettaLucy L RussellRhian S ConveryGeorgia PeakmanEmily G ToddDavid M CashCaroline V GreavesJohn van SwietenLize JiskootHarro SeelaarFermin MorenoRaquel Sanchez-ValleBarbara BorroniRobert Jr LaforceMario MasellisMaria Carmela TartagliaCaroline GraffDaniela GalimbertiJames B RoweElizabeth FingerMatthis SynofzikRik VandenbergheAlexandre de MendonçaFabrizio TagliaviniIsabel SantanaSimon DucharmeChris ButlerAlex GerhardJohannes LevinAdrian DanekMarkus OttoSandro SorbiSteven C R WilliamsDaniel C AlexanderJonathan D Rohrernull nullPublished in: Neurology (2021)
Our results demonstrate that different MAPT mutations give rise to distinct atrophy patterns and clinical phenotype, providing insights into the underlying disease biology and potential utility for patient stratification in therapeutic trials.
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