Enhanced notch signaling modulates unproductive revascularization in response to nitric oxide-angiopoietin signaling in a mouse model of peripheral ischemia.
Maria J C MachadoRachel BoardmanFederica RiuCostanza EmanueliAndrew V BenestDavid O BatesPublished in: Microcirculation (New York, N.Y. : 1994) (2019)
These results suggest that Dll4 activation early on in revascularization can lead to unproductive angiogenesis and arteriolargenesis, despite increased vascular densities. These results suggest spatial and temporal balance of growth factors needs to be perfected for ideal functional and anatomical revascularisation.