SPAK inhibitor ZT-1a attenuates reactive astrogliosis and oligodendrocyte degeneration in a mouse model of vascular dementia.

Mohammad Iqbal H Bhuiyan Khadija HabibMd Tipu SultanFenghua ChenIsrat JahanZhongfang WengMd Shamim RahmanRabia IslamLesley M FoleyT Kevin HitchensXianming DengScott W CannaDandan SunGuodong Cao

Published in: CNS neuroscience & therapeutics (2024)

BCAS-induced upregulation of WNK-SPAK-NKCC1 signaling contributes to white matter-reactive astrogliosis, OL death, and memory impairment. Pharmacological inhibition of the SPAK activity has therapeutic potential for alleviating pathogenesis and memory impairment in VCID.

Keyphrases

white matter
mouse model
working memory
high glucose
mild cognitive impairment
diabetic rats
multiple sclerosis
cell proliferation
cognitive impairment
signaling pathway
drug induced
endothelial cells
stress induced