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Sleep improvement is associated with the antidepressant efficacy of repeated-dose ketamine and serum BDNF levels: a post-hoc analysis.

Mingqia WangBin ZhangYangling ZhouChengyu WangWei ZhengWeijian LiuYanni ZhanXiaofeng LanYuping Ning
Published in: Pharmacological reports : PR (2021)
In the 127 patients, six ketamine infusions induced better therapeutic effects in sleep responders than in sleep non-responders and patients without sleep disturbances. The sleep response after repeated ketamine infusions was positively associated with high serum BDNF levels. Early sleep disturbance improvement (as early as 24 h after the first ketamine injection) may predict the antidepressant effect of repeated-dose ketamine.
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