Role of plasma angiotensin II and angiotensin-converting enzyme 2 levels on prognosis and mortality in hypertensive patients with COVID-19.
Serap BiberoğluAfşin İpekciİbrahim İkizceliFatih ÇakmakYonca S AkdenizAltuğ KanbakanDildar Konukogluİbrahim Murat BolayırlıŞermin BörekciSeval ÜrkmezSeda OzkanPublished in: Biomarkers in medicine (2021)
Introduction: SARS-CoV-2 requires angiotensin-converting enzyme 2 (ACE2) to enter the cell. In our study, we aimed to investigate the role of angiotensin-converting enzyme 2 and angiotensin II plasma levels on prognosis and mortality in patients with isolated hypertension, patients with chronic diseases in addition to hypertension and patients with COVID-19 without comorbidities, in accordance with the use of renin-angiotensin-aldosterone system inhibitor. Materials & methods: In the study, patients diagnosed with COVID-19 were divided into three groups. Angiotensin II and ACE2 levels were compared by comorbidities, antihypertensive drugs used, intensive care hospitalization and termination of patients. The relationship between angiotensin II and ACE2 levels and service and intensive care times was investigated. Findings: A total of 218 patients were enrolled in our study, including 68 patients diagnosed with COVID-19 without comorbidities, 33 patients diagnosed with isolated hypertension and 117 patients with other chronic diseases in addition to hypertension. There was no statistically significant difference between the comorbid disease groups between angiotensin II and ACE2 levels of the patients enrolled in the study. The rate of patients admitted to the intensive care unit was 17.9%, and the mortality rate was 11.5%. Results: In our study, we did not obtain significant findings regarding angiotensin II and ACE2 levels on presentation that can be used in prognosis and mortality of COVID-19 patients and development of future treatment methods.
Keyphrases
- angiotensin ii
- angiotensin converting enzyme
- vascular smooth muscle cells
- sars cov
- end stage renal disease
- ejection fraction
- blood pressure
- newly diagnosed
- chronic kidney disease
- prognostic factors
- stem cells
- patient reported outcomes
- mental health
- healthcare
- bone marrow
- risk factors
- mesenchymal stem cells
- respiratory syndrome coronavirus
- high resolution
- case report
- cardiovascular events
- high speed
- single molecule