Blocking of efflux transporters in rats improves translational validation of brain radioligands.
Vladimir ShalgunovMengfei XiongElina T L'EstradeNakul Ravi RavalIda V AndersenFraser G EdgarNikolaj R SpethSimone L BaerentzenHanne Demant HansenLene L DonovanArafat NasserSiv T PeitersenAndreas KjaerGitte M KnudsenStina SyvänenMikael PalnerMatthias Manfred HerthPublished in: EJNMMI research (2020)
P-gp strongly affects the uptake of PET tracers in rodents, but false prediction outcomes can be reduced by evaluating a tracer under P-gp inhibition.