Exploring causal association between circulating inflammatory cytokines and functional outcomes following ischemic stroke: A bidirectional Mendelian randomization study.

Huacong LiuZhaoxing LiuYumeng HuangQian DingZhenyi LaiXiaowen CaiShengtao HuangLianjun YinXiaoyan ZhengYong HuangJunqi Chen

Published in: European journal of neurology (2023)

This study suggests a causality between inflammation and adverse functional outcomes following IS. RANTES (CCL5) and EOTAXIN (CCL11) may be the upstream factors of adverse functional outcomes following IS, while IL-18 may be the downstream effect of adverse functional outcomes following IS. Whether these cytokines can be used to predict or improve adverse functional outcomes after IS requires further researches.

Keyphrases

adverse drug
emergency department
atrial fibrillation
liver fibrosis
drug induced