Macrotricolorin A, a new diarylpropanoid from the Vietnamese plant Macrosolen tricolor (Lecomte) Danser.
Kieu Hung LeThi Kim Ngan BuiNguyen Kim Tuyen PhamVan Son DangTrong Nghia NgoNhat Minh PhanTrong Dat BuiTrong Duc TranQuan Hien NguyenQuoc Luan NgoDinh Tri MaiNguyen Kim Tuyen PhamPublished in: Natural product research (2020)
From the Vietnamese plant Macrosolen tricolor (Lecomte) Danser, one new diarylpropanoid, named macrotricolorin A (1) together with three diarylheptanoids including bisdemethoxycurcumin (2), demethoxycurcumin (3) and curcumin (4), were isolated. Their structures were elucidated by intensive analyses of their IR, UV, HR-ESI-MS and NMR (1 D & 2 D) spectra. It is the first time that diarylalkanoids have been reported from the genus Macrosolen. Compound 1 exhibited anti-inflammatory activity against the nitric oxide (NO) production in lipopolysaccharide (LPS)-induced RAW264.7 with an IC50 value of 27.54 ± 1.75 μM.