Design, synthesis, molecular docking studies and biological evaluation of thiazole carboxamide derivatives as COX inhibitors.
Mohammed HawashNidal JaradatMurad AbualhasanMurat Kadır ŞüküroğluMohammed T QaoudDeniz Cansen KahramanHeba DaraghmehLeen MaslamaniMais SawaftaAla RatroutLinda IssaPublished in: BMC chemistry (2023)
In general, the series of the synthesized compounds had a strong effect on both enzymes (COX-1 and COX-2) and the trimethoxy compound 2f was more selective than the other compounds.