Prior Exposure to Experimental Preeclampsia Increases Atherosclerotic Plaque Inflammation in Atherogenic Mice.
Lauren A BiwerJoshua J ManNicholas D CamardaBrigett V CarvajalS Ananth KarumanchiIris Z JaffePublished in: Arteriosclerosis, thrombosis, and vascular biology (2024)
In atherogenic LDLR-KO mice, exposure to sFlt1-induced preeclampsia during pregnancy increases future atherosclerotic plaque inflammation, supporting the concept that preeclampsia directly exacerbates atherosclerotic inflammation independent of preexisting risk factors. This mechanism may contribute to ischemic vascular disease in women after preeclampsia pregnancy.
Keyphrases
- pregnancy outcomes
- early onset
- oxidative stress
- risk factors
- pregnant women
- coronary artery disease
- high fat diet induced
- diabetic rats
- type diabetes
- current status
- metabolic syndrome
- adipose tissue
- wild type
- insulin resistance
- cerebral ischemia
- skeletal muscle
- drug induced
- blood brain barrier
- endothelial cells
- subarachnoid hemorrhage