Elevated methylation of the vault RNA2-1 promoter in maternal blood is associated with preterm birth.

Young-Ah YouEun Jin KwonHan-Sung HwangSuk-Joo ChoiSae Kyung ChoiYoung Ju Kim

Published in: BMC genomics (2021)

VTRNA2-1 is a noncoding transcript to environmentally responsive epialleles. Our results suggest that elevated methylation of the VTRNA2-1 promoter may result in increased risk of PTB caused by the pro-inflammatory cytokines. Further studies are needed to confirm the association of VTRNA2-1 methylation with preterm birth in a large population, and to elucidate the underlying mechanism.

Keyphrases

preterm birth
dna methylation
genome wide
gestational age
low birth weight
birth weight
gene expression
transcription factor
body mass index
pregnancy outcomes
physical activity