Glial activation and inflammation along the Alzheimer's disease continuum.
Kaja NordengenBjørn-Eivind KirsebomKristi HenjumPer SelnesBerglind GísladóttirMarianne WettergreenSilje Bøen TorsetnesGøril Rolfseng GrøntvedtKnut K WaterlooDag AarslandLars N G NilssonTormod FladbyPublished in: Journal of neuroinflammation (2019)
Microglial activation as indicated by increased sTREM2 is present already at the preclinical SCD stage; increased MCP-1 and astroglial activation markers (YKL-40 and clusterin) were noted only at the MCI and AD dementia stages, respectively, and in Aβ+ cases (A+) with pathological T-tau (N+). Possible different effects of early and later glial activation need to be explored.