The Omega-6 Lipid pathway shift is associated with neutrophil influx and structural lung damage in early cystic fibrosis lung disease.

Lisa Jm SlimmenJelle Y BroosBadies Han ManaïSilvia C EstevãoMartin GieraGijs KooijWendy Wj UngerHettie M Janssens

Published in: Clinical & translational immunology (2024)

Our data provide more insight into the lung lipidome of infants with CF, and show that a shift from LA derivatives to AA derivatives in BALF associates with early CF lung disease progression.

Keyphrases

cystic fibrosis
pseudomonas aeruginosa
lung function
oxidative stress
machine learning
chronic obstructive pulmonary disease
structure activity relationship
big data
artificial intelligence