MR1-dependent immune surveillance of the skin contributes to pathogenesis and is a photobiological target of UV light therapy in a mouse model of atopic dermatitis.

Karmella NaidooKatherine WoodsChristophe PellefiguesAlissa CaitDavid O'SullivanKatie GellAndrew J MarshallRegan J AndersonYanyan LiAlfonso SchmidtKef PrasitJohannes U MayerAurelie GestinIan F HermansGavin PainterElizabeth A JacobsenOlivier Gasser

Published in: Allergy (2021)

We identified MAIT cells as sentinels and mediators of cutaneous type 2 immunity. Their pathogenic activity can be inhibited by topical application or endogenous generation, via phototherapy, of inhibitory MR1 ligands.

Keyphrases

atopic dermatitis
mouse model
induced apoptosis
contrast enhanced
wound healing
cell cycle arrest
magnetic resonance
public health
soft tissue
endoplasmic reticulum stress
oxidative stress
cell death
computed tomography
signaling pathway
stem cells
bone marrow
cell proliferation