Comparative proteomics analysis of transforming growth factor-beta1-overexpressed human dental pulp stem cell-derived secretome on CD44-mediated fibroblast activation via canonical smad signal pathway.

Hasan Salkın Mustafa Burak Acar Zeynep Burçin Gönen Kemal Erdem Basaran Servet Ozcan

Published in: Connective tissue research (2022)

While TGF-β1-transfected hDPSC secretome may be a potential therapeutic candidate in regenerative connective tissue therapies as it induces fibroblast activation, anti-TGF-β1-based therapies would be considered in histopathological conditions such as pulmonary fibrosis or hepatic fibrosis.

Keyphrases

transforming growth factor
epithelial mesenchymal transition
pulmonary fibrosis
stem cells
endothelial cells
cell therapy
induced pluripotent stem cells
wound healing
tissue engineering
bone marrow
liver fibrosis