Evaluation of dual p16/Ki-67 immunostaining on anal cytology specimens.

Marie C SmithgallWilliam S TowneAbel A GonzalezAdela Cimic

Published in: Diagnostic cytopathology (2024)

Dual p16/Ki-67 staining indicates transforming HPV infection and could help serve as an ancillary test for risk stratification for atypical anal cytology specimens. Among ASCUS samples, dual staining was specific for SIL of any grade with a high negative predictive value and therefore could be useful in clinical practices with limited availability for follow-up care.

Keyphrases

high grade
fine needle aspiration
healthcare
ultrasound guided
primary care
palliative care
squamous cell carcinoma
quality improvement
flow cytometry
lymph node
health insurance
rectal cancer
cervical cancer screening