Spleen regeneration after subcutaneous heterotopic autotransplantation in a mouse model.

Andrey V ElchaninovPolina VishnyakovaAnastasiya LokhoninaViktoria KiselevaEgor MenyailoMaria AntonovaAiaz MamedovIrina ArutyunyanGalina BolshakovaDmitry GoldshteinXuhui BaoTimur FatkhudinovGennady Sukhikh

Published in: Biological research (2023)

Allogeneic subcutaneous transplantation of splenic fragments in a mouse model leads to their structural recovery within 30 days, with full reconstitution of the monocyte-macrophage, megakaryocyte and B lymphocyte populations. The circulating hematopoietic cells provide the likely source for the cell composition recovery.

Keyphrases

mouse model
bone marrow
induced apoptosis
cell therapy
stem cell transplantation
stem cells
cell cycle arrest
single cell
dendritic cells
adipose tissue
endoplasmic reticulum stress
signaling pathway
immune response
oxidative stress
wound healing
pi k akt
mesenchymal stem cells